RNA乙酰化修飾：ac4C測序 acRIP-seq

1.Zhan YJ, Deng CM, Tang L, et al. NAT10 Increases Lysosomal Acidification to Promote Esophageal Cancer Metastasis via ac4C Acetylation of ATP6V0E1 mRNA. Adv Sci (Weinh). 2025;12(31):e02931. 2.Lei X, Zheng B, Peng Y, et al. Targeting the NAT10/XIST/YAP1 Axis-Mediated Vascular Abnormalization Enhances Immune Checkpoint Blockade in Gastric Cancer. Int J Biol Sci. 2025;21(11):4997-5014. Published 2025 Jul 28. 3.Liu WC, Wei YH, Chen JF, et al. Inhibition of tumor-intrinsic NAT10 enhances antitumor immunity by triggering type I interferon response via MYC/CDK2/DNMT1 pathway. Nat Commun. 2025;16(1):5154. Published 2025 Jun 3. 4.Dai Y, Li Y, Yang X, et al. Silencing the fibronectin gene (FN1) improves NaCl-induced cardiac fibrosis via ferritinophagy-mediated ferroptosis in a nuclear receptor coactivator 4 (NCOA4)-dependent manner. Br J Pharmacol. 2026;183(3):581-597. 5.Wan X, Wang L, Khan MA, et al. NAT10-mediated N4-acetylcytidine modification in KLF9 mRNA promotes adipogenesis. Cell Death Differ. 2025;32(9):1613-1629. 6.Wang L, Chen E, Zhang S, et al. Targeting the ac4C 'Writer' NAT10 enhances pancreatic cancer immunotherapy via dual modulation of CD8+ T cells and tumor cells. Cell Death Dis. 2025;16(1):809. Published 2025 Nov 7. 7.Xiao Z, Wei X, Li P, et al. Impact of N-acetyltransferase 10 on macrophage activation and inflammation-induced cardiac dysfunction. Cell Death Dis. 2025;16(1):471. Published 2025 Jul 1. 8.Li H, Wu H, Li S, et al. Mechanistic study of N-acetyltransferase 10 deficiency enhancing olaparib sensitivity in triple negative breast cancer by inhibiting RAD51 N4-acetylcytidine modification. iScience. 2025;28(7):112860. Published 2025 Jun 9. 9.Song A, Liu B, Li W, et al. Competitive binding between DDX21 and SIRT7 enhances NAT10-mediated ac4C modification to promote colorectal cancer metastasis and angiogenesis- DDX21 promotes colorectal cancer metastasis. Cell Death Dis. 2025;16(1):353. Published 2025 Apr 29. 10.Yu C, Chen Y, Luo H, et al. NAT10 promotes vascular remodelling via mRNA ac4C acetylation. Eur Heart J. 2025;46(3):288-304. 11.Huang T, Zhang Y, Niu Y, Xiao Y, Ge Y, Gao J. The Cytidine N-Acetyltransferase NAT10 Promotes Thalamus Hemorrhage-Induced Central Poststroke Pain by Stabilizing Fn14 Expression in Thalamic Neurons. Mol Neurobiol. 2025;62(3):3276-3292. 12.Xie H, Zhang K, Yin H, et al. Acetyltransferase NAT10 inhibits T-cell immunity and promotes nasopharyngeal carcinoma progression through DDX5/HMGB1 axis. J Immunother Cancer. 2025;13(2):e010301. Published 2025 Feb 12. 13.Zhang X, Zheng Y, Yang J, et al. Abnormal ac4C modification in metabolic dysfunction associated steatotic liver cells. Sci Rep. 2025;15(1):1013. Published 2025 Jan 6. 14.Li KJ, Hong Y, Yu YZ, et al. NAT10 Promotes Prostate Cancer Growth and Metastasis by Acetylating mRNAs of HMGA1 and KRT8. Adv Sci (Weinh). 2024;11(32):e2310131. 15.Xie R, Cheng L, Huang M, et al. NAT10 drives cisplatin chemoresistance by enhancing ac4C-associated DNA repair in  bladder cancer. Cancer Res 2023 Mar 20.[2] Yang Q, Lei X, He J, et al. N4-Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF-1α Positive Feedback Loop. Adv Sci (Weinh). 2023 Aug;10(23):e2300898. 16.Shi J, Yang C, Zhang J, et al. NAT10 Is Involved in Cardiac Remodeling Through ac4C-Mediated Transcriptomic Regulation. Circ Res. 2023 Dec 8;133(12):989-1002. 17.Yan Q, Zhou J, Wang Z, et al. NAT10-dependent N4-acetylcytidine modification mediates PAN RNA stability, KSHV reactivation, and IFI16-related inflammasome activation. Nat Commun. 2023 Oct 10;14(1):6327.